This learning session will explore the use of NSAIDs in chronic pain. We will review the OTC and prescription NSAIDs that are commonly employed, how they differ from each other, and how they differ from non-NSAIDs. We will then explore the safety and efficacy of these drugs, while simultaneously highlighting and emphasizing clinical pearls. Lastly, we will apply the information to a patient case scenario to develop a treatment and monitoring plan for the use of NSAIDs in chronic pain.