While marijuana is not new, the potency, ratios of tetrahydrocannabinol/cannabidiol, concentrated products called budder or shatter and edibles are different and present related but unique problems. General increased awareness of prescription drug *misuse led to prescription drug monitoring programs and decreased prescribing of commonly *misused medications. As a result, some patients switched to *misusing medications that are more surprising. Attendees will gain familiarity with newer substances of *misuse and newer forms of or ways to use older substances of *misuse, as well as how and perhaps why we are in the current circumstance of increased substance use, *misuse and poor outcomes.